Be Aware Canagliflozin Might Increase Amputation Risk in Diabetes Patients

Reports of amputation with canagliflozin (Invokana, Invokamet) will raise more questions about the safety of SGLT2 inhibitors.

This is the latest in a growing list of "flozin" concerns...ketoacidosis, urinary tract infections, yeast infections, etc.

Amputations, mainly of the toe or mid-foot, are seen in about 6 in 1,000 patients taking canagliflozin per year...compared to about 3 in 1,000 patients per year on other diabetes meds.

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