St. John's wort interacts with digoxin

January 2000

New evidence suggests that St. John's wort interacts with digoxin...and lowers digoxin serum concentrations about 25%.

Researchers suspect that St. John's wort reduces digoxin absorption...possibly by inducing P-glycoprotein in the gut.

P-glycoprotein helps eliminate drugs in the intestine and kidney. It works by transporting drugs OUT of cells...into the gut or renal tubule for excretion.

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