dissolution changes with a new Dilantin (phenytoin) formulation

December 2002

Pfizer is notifying pharmacists about dissolution changes with a new Dilantin (phenytoin) formulation.

Dilantin 100 mg extended release capsules were reformulated with a new filler that affects dissolution.

This new formulation dissolves differently...and doesn't pass the standard dissolution test called "USP Test 1."

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Table of Contents

new approaches for preventing a SECOND heart attack
rheumatoid arthritis patients getting BOTH methotrexate plus Arava (leflunomide)
Cardiology using digoxin in WOMEN with heart failure might do more harm than good
Cardiology statins do much more than just lower cholesterol
Cardiology Ezetrol will be the first "cholesterol absorption inhibitor" for hyperlipidemia
Obesity & Weight Loss Topamax (topiramate) for obesity
Ophthalmology Xalacom, the first prostaglandin analog combo product for glaucoma
Gastroenterology irritable bowel syndrome (IBS) patients can benefit from SSRIs
Men's Health drugs compete with Proscar (finasteride) for benign prostatic hyperplasia
Dermatology duct tape for common warts
Natural Medicines questions about coral calcium.
Natural Medicines Many patients don't realize fortified foods can interact with their medications
dissolution changes with a new Dilantin (phenytoin) formulation
Abilify (a-BILA-fī), a new antipsychotic for schizophrenia
questions about smallpox
Commit Lozenge that's expected in Canada next year