serotonin syndrome in HIV patients taking both fluoxetine(Prozac) and ritonavir (Norvir, Kaletra

September 2001

There are now reports of serotonin syndrome in HIV patients taking both fluoxetine (Prozac) and ritonavir (Norvir, Kaletra).

Ritonavir is a potent inhibitor of cytochrome P450 enzymes... and can slow the metabolism of fluoxetine.

The combination can lead to symptoms of serotonin syndrome...confusion, muscle spasms, tremor, fever, anxiety, etc.

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