Help Spot Patients Prescribed Amiodarone and Harvoni
We're getting questions about how to handle interaction alerts between amiodarone (Cordarone, etc) and sofosbuvir (Sovaldi, Harvoni).
Combining amiodarone with sofosbuvir-containing hepatitis C regimens may lead to a patient's heart rate slowing to a dangerous level...or may cause the heart to stop altogether.
Exactly how this interaction happens is still up for debate. Researchers are looking for possible mechanisms...or to see if the case reports are just due to chance.